Studies of the pharmacokinetic properties of nimorazole.

The pharmacokinetics of the hypoxic radio-sensitizer nimorazole were studied in 19 individuals after single oral doses of between 0.5-3.5 g. HPLC measurements showed, after a rapid absorption, a linear relationship between peak plasma concentration and given dose. Mean elimination half life was 3.1...

Descripción completa

Detalles Bibliográficos
Autores principales: Overgaard, J., Overgaard, M., Timothy, A. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011427/
https://www.ncbi.nlm.nih.gov/pubmed/6871077
_version_ 1782136527755673600
author Overgaard, J.
Overgaard, M.
Timothy, A. R.
author_facet Overgaard, J.
Overgaard, M.
Timothy, A. R.
author_sort Overgaard, J.
collection PubMed
description The pharmacokinetics of the hypoxic radio-sensitizer nimorazole were studied in 19 individuals after single oral doses of between 0.5-3.5 g. HPLC measurements showed, after a rapid absorption, a linear relationship between peak plasma concentration and given dose. Mean elimination half life was 3.1 h. A tendency to a dose-dependent variation in the apparent volume of distribution, total body clearance and elimination half life suggest non-linear pharmacokinetics of nimorazole. Tumour concentrations measured in 5 patients gave tumour/plasma ratios between 0.8-1.3. No toxicity was observed. The results indicate that nimorazole may have potential as a clinically useful hypoxic radiosensitizer.
format Text
id pubmed-2011427
institution National Center for Biotechnology Information
language English
publishDate 1983
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20114272009-09-10 Studies of the pharmacokinetic properties of nimorazole. Overgaard, J. Overgaard, M. Timothy, A. R. Br J Cancer Research Article The pharmacokinetics of the hypoxic radio-sensitizer nimorazole were studied in 19 individuals after single oral doses of between 0.5-3.5 g. HPLC measurements showed, after a rapid absorption, a linear relationship between peak plasma concentration and given dose. Mean elimination half life was 3.1 h. A tendency to a dose-dependent variation in the apparent volume of distribution, total body clearance and elimination half life suggest non-linear pharmacokinetics of nimorazole. Tumour concentrations measured in 5 patients gave tumour/plasma ratios between 0.8-1.3. No toxicity was observed. The results indicate that nimorazole may have potential as a clinically useful hypoxic radiosensitizer. Nature Publishing Group 1983-07 /pmc/articles/PMC2011427/ /pubmed/6871077 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Overgaard, J.
Overgaard, M.
Timothy, A. R.
Studies of the pharmacokinetic properties of nimorazole.
title Studies of the pharmacokinetic properties of nimorazole.
title_full Studies of the pharmacokinetic properties of nimorazole.
title_fullStr Studies of the pharmacokinetic properties of nimorazole.
title_full_unstemmed Studies of the pharmacokinetic properties of nimorazole.
title_short Studies of the pharmacokinetic properties of nimorazole.
title_sort studies of the pharmacokinetic properties of nimorazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011427/
https://www.ncbi.nlm.nih.gov/pubmed/6871077
work_keys_str_mv AT overgaardj studiesofthepharmacokineticpropertiesofnimorazole
AT overgaardm studiesofthepharmacokineticpropertiesofnimorazole
AT timothyar studiesofthepharmacokineticpropertiesofnimorazole

Ejemplares similares