Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.

Misonidazole (MISO) given as a large single dose enhanced the action of cyclophosphamide (Cy) and melphalan (L-PAM) in two mouse tumours. Below a dose of about 500 mg kg-1 it had no chemosensitizing effect. When MISO was given as a series of small doses by repeat injection over an 8 h period, in ord...

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Autores principales: McNally, N. J., Hinchliffe, M., de Ronde, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011437/
https://www.ncbi.nlm.nih.gov/pubmed/6882665
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author McNally, N. J.
Hinchliffe, M.
de Ronde, J.
author_facet McNally, N. J.
Hinchliffe, M.
de Ronde, J.
author_sort McNally, N. J.
collection PubMed
description Misonidazole (MISO) given as a large single dose enhanced the action of cyclophosphamide (Cy) and melphalan (L-PAM) in two mouse tumours. Below a dose of about 500 mg kg-1 it had no chemosensitizing effect. When MISO was given as a series of small doses by repeat injection over an 8 h period, in order to stimulate human pharmacokinetics, it significantly enhanced the action of Cy in the SA F tumour. It also enhanced the action of Cy and L-PAM in the WHFIB tumour as assayed by tumour cell survival in vitro following treatment in vivo but not when the assay was tumour growth delay. There was no enhancement by MISO of the leukopenia due to Cy or L-PAM. The results suggest that, in some tumours there may be benefit from the combination of clinically relevant MISO doses with alkylating agents. The leucopenia induced by these agents should not be enhanced by the MISO.
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spelling pubmed-20114372009-09-10 Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole. McNally, N. J. Hinchliffe, M. de Ronde, J. Br J Cancer Research Article Misonidazole (MISO) given as a large single dose enhanced the action of cyclophosphamide (Cy) and melphalan (L-PAM) in two mouse tumours. Below a dose of about 500 mg kg-1 it had no chemosensitizing effect. When MISO was given as a series of small doses by repeat injection over an 8 h period, in order to stimulate human pharmacokinetics, it significantly enhanced the action of Cy in the SA F tumour. It also enhanced the action of Cy and L-PAM in the WHFIB tumour as assayed by tumour cell survival in vitro following treatment in vivo but not when the assay was tumour growth delay. There was no enhancement by MISO of the leukopenia due to Cy or L-PAM. The results suggest that, in some tumours there may be benefit from the combination of clinically relevant MISO doses with alkylating agents. The leucopenia induced by these agents should not be enhanced by the MISO. Nature Publishing Group 1983-08 /pmc/articles/PMC2011437/ /pubmed/6882665 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McNally, N. J.
Hinchliffe, M.
de Ronde, J.
Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title_full Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title_fullStr Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title_full_unstemmed Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title_short Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
title_sort enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011437/
https://www.ncbi.nlm.nih.gov/pubmed/6882665
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