Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.

Clofibrate (CPIB) is a drug applied as an antilipidaemic agent in mammals. In this work we have tested its efficacy in vivo on the growth kinetics of P 1798(sc) lymphoma transplanted to recipient (BALB/c x AKR)F1 mice. Our results show a facilitation of the tumour growth rate in treated recipients....

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Autores principales: Ubeira, F. M., Seoane, R., Puentes, E., Faro, J., Regueiro, B. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011464/
https://www.ncbi.nlm.nih.gov/pubmed/6351886
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author Ubeira, F. M.
Seoane, R.
Puentes, E.
Faro, J.
Regueiro, B. J.
author_facet Ubeira, F. M.
Seoane, R.
Puentes, E.
Faro, J.
Regueiro, B. J.
author_sort Ubeira, F. M.
collection PubMed
description Clofibrate (CPIB) is a drug applied as an antilipidaemic agent in mammals. In this work we have tested its efficacy in vivo on the growth kinetics of P 1798(sc) lymphoma transplanted to recipient (BALB/c x AKR)F1 mice. Our results show a facilitation of the tumour growth rate in treated recipients. This fact may be related to an effect of the agent on the recipient which produces a decrease in the immune response as was confirmed on testing CPIB on thymus-dependent antigens in haemolytic plaque assays. IMAGES:
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spelling pubmed-20114642009-09-10 Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma. Ubeira, F. M. Seoane, R. Puentes, E. Faro, J. Regueiro, B. J. Br J Cancer Research Article Clofibrate (CPIB) is a drug applied as an antilipidaemic agent in mammals. In this work we have tested its efficacy in vivo on the growth kinetics of P 1798(sc) lymphoma transplanted to recipient (BALB/c x AKR)F1 mice. Our results show a facilitation of the tumour growth rate in treated recipients. This fact may be related to an effect of the agent on the recipient which produces a decrease in the immune response as was confirmed on testing CPIB on thymus-dependent antigens in haemolytic plaque assays. IMAGES: Nature Publishing Group 1983-09 /pmc/articles/PMC2011464/ /pubmed/6351886 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ubeira, F. M.
Seoane, R.
Puentes, E.
Faro, J.
Regueiro, B. J.
Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title_full Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title_fullStr Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title_full_unstemmed Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title_short Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma.
title_sort effect of clofibrate on the growth-kinetics of the murine p 1798(sc) lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011464/
https://www.ncbi.nlm.nih.gov/pubmed/6351886
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