The sex hormone profile of male patients with breast cancer.

The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significa...

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Autores principales: Nirmul, D., Pegoraro, R. J., Jialal, I., Naidoo, C., Joubert, S. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011477/
https://www.ncbi.nlm.nih.gov/pubmed/6684472
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author Nirmul, D.
Pegoraro, R. J.
Jialal, I.
Naidoo, C.
Joubert, S. M.
author_facet Nirmul, D.
Pegoraro, R. J.
Jialal, I.
Naidoo, C.
Joubert, S. M.
author_sort Nirmul, D.
collection PubMed
description The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin. DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17 beta is an important factor in the aetiology of hormone-dependent male breast cancer.
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spelling pubmed-20114772009-09-10 The sex hormone profile of male patients with breast cancer. Nirmul, D. Pegoraro, R. J. Jialal, I. Naidoo, C. Joubert, S. M. Br J Cancer Research Article The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin. DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17 beta is an important factor in the aetiology of hormone-dependent male breast cancer. Nature Publishing Group 1983-09 /pmc/articles/PMC2011477/ /pubmed/6684472 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nirmul, D.
Pegoraro, R. J.
Jialal, I.
Naidoo, C.
Joubert, S. M.
The sex hormone profile of male patients with breast cancer.
title The sex hormone profile of male patients with breast cancer.
title_full The sex hormone profile of male patients with breast cancer.
title_fullStr The sex hormone profile of male patients with breast cancer.
title_full_unstemmed The sex hormone profile of male patients with breast cancer.
title_short The sex hormone profile of male patients with breast cancer.
title_sort sex hormone profile of male patients with breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011477/
https://www.ncbi.nlm.nih.gov/pubmed/6684472
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