Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.

Our studies of the metastatic behaviour of FSA1231 and FSA1233 show that the role of selection processes of metastatic variants at the secondary sites is minimal in the spontaneous metastasis of these systems. In contrast, tumour-cell release efficiency (number of blood-borne clonogenic tumour-cells...

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Detalles Bibliográficos
Autor principal: Suzuki, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011557/
https://www.ncbi.nlm.nih.gov/pubmed/6652022
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author Suzuki, N.
author_facet Suzuki, N.
author_sort Suzuki, N.
collection PubMed
description Our studies of the metastatic behaviour of FSA1231 and FSA1233 show that the role of selection processes of metastatic variants at the secondary sites is minimal in the spontaneous metastasis of these systems. In contrast, tumour-cell release efficiency (number of blood-borne clonogenic tumour-cells) correlates well with the difference in spontaneous lung metastasis efficiencies of the cell clones FSA1231 and FSA1233. Also, the different tumour-cell release efficiencies could explain the discrepancy between artificial and spontaneous metastasis of these cell clones. IMAGES:
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spelling pubmed-20115572009-09-10 Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones. Suzuki, N. Br J Cancer Research Article Our studies of the metastatic behaviour of FSA1231 and FSA1233 show that the role of selection processes of metastatic variants at the secondary sites is minimal in the spontaneous metastasis of these systems. In contrast, tumour-cell release efficiency (number of blood-borne clonogenic tumour-cells) correlates well with the difference in spontaneous lung metastasis efficiencies of the cell clones FSA1231 and FSA1233. Also, the different tumour-cell release efficiencies could explain the discrepancy between artificial and spontaneous metastasis of these cell clones. IMAGES: Nature Publishing Group 1983-12 /pmc/articles/PMC2011557/ /pubmed/6652022 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Suzuki, N.
Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title_full Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title_fullStr Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title_full_unstemmed Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title_short Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
title_sort variant selection and blood-borne "clonogenic" tumour cells in metastasis of fsa cell clones.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011557/
https://www.ncbi.nlm.nih.gov/pubmed/6652022
work_keys_str_mv AT suzukin variantselectionandbloodborneclonogenictumourcellsinmetastasisoffsacellclones

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