Centrosomal pre-integration latency of HIV-1 in quiescent cells

Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells in vitro. The molecular basis of this restriction is still poorly understood. Here, we show that in quiesce...

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Detalles Bibliográficos
Autores principales: Zamborlini, Alessia, Lehmann-Che, Jacqueline, Clave, Emmanuel, Giron, Marie-Lou, Tobaly-Tapiero, Joëlle, Roingeard, Philippe, Emiliani, Stéphane, Toubert, Antoine, de Thé, Hugues, Saïb, Ali
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014762/
https://www.ncbi.nlm.nih.gov/pubmed/17845727
http://dx.doi.org/10.1186/1742-4690-4-63
Descripción
Sumario:Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells in vitro. The molecular basis of this restriction is still poorly understood. Here, we show that in quiescent cells, incoming HIV-1 sub-viral complexes concentrate and stably reside at the centrosome for several weeks. Upon cell activation, viral replication resumes leading to viral gene expression. Thus, HIV-1 can persist in quiescent cells as a stable, centrosome-associated, pre-integration intermediate.

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