Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

Push–pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity. In a push–pull network, two antagonistic enzymes control the activity of a protein by covalent mo...

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Detalles Bibliográficos
Autores principales: van Albada, Siebe B, ten Wolde, Pieter Rein
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014792/
https://www.ncbi.nlm.nih.gov/pubmed/17937496
http://dx.doi.org/10.1371/journal.pcbi.0030195

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