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HMBA Releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and Activates HIV Transcription

Hexamethylene bisacetamide (HMBA) is a potent inducer of cell differentiation and HIV production in chronically infected cells. However, its mechanism of action remains poorly defined. In this study, we demonstrate that HMBA activates transiently the PI3K/Akt pathway, which leads to the phosphorylat...

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Detalles Bibliográficos
Autores principales:	Contreras, Xavier, Barboric, Matjaz, Lenasi, Tina, Peterlin, B. Matija
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014796/ https://www.ncbi.nlm.nih.gov/pubmed/17937499 http://dx.doi.org/10.1371/journal.ppat.0030146

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