DNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in HT-29 cells

Functional loss of both alleles of the breast cancer susceptibility gene, BRCA2, facilitates tumorigenesis. However, the direct effects of BRCA2 heterozygosity remain unclear. Here, BRCA2 heterozygosity was mimicked in HT-29 colon cells by reducing levels of BRCA2 through stable RNA interference. No...

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Detalles Bibliográficos
Autores principales: Tannenbaum, Brian, Mofunanya, Tobechukwu, Schoenfeld, Alan R.
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2007
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2017108/
https://www.ncbi.nlm.nih.gov/pubmed/17940634

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