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Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

Human (h)PTIP plays important but poorly understood roles in cellular responses to DNA damage. hPTIP interacts with 53BP1 tumour suppressor but only when 53BP1 is phosphorylated by ATM after DNA damage although the mechanism(s) and significance of the interaction of these two proteins are unclear. H...

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Detalles Bibliográficos
Autores principales: Munoz, Ivan M., Jowsey, Paul A., Toth, Rachel, Rouse, John
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018624/
https://www.ncbi.nlm.nih.gov/pubmed/17690115
http://dx.doi.org/10.1093/nar/gkm493