Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair (BER) is the primary DNA repair pathway for small base modifications such as alkylation, deamina...

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Detalles Bibliográficos
Autores principales: Weissman, Lior, Jo, Dong-Gyu, Sørensen, Martin M., de Souza-Pinto, Nadja C., Markesbery, William R., Mattson, Mark P., Bohr, Vilhelm A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018628/
https://www.ncbi.nlm.nih.gov/pubmed/17704129
http://dx.doi.org/10.1093/nar/gkm605

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