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Mitotic regulation by NIMA-related kinases

The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast homologue Fin1, contribute to multiple aspects of mitotic progression including the timi...

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Autores principales: O'Regan, Laura, Blot, Joelle, Fry, Andrew M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018689/
https://www.ncbi.nlm.nih.gov/pubmed/17727698
http://dx.doi.org/10.1186/1747-1028-2-25
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author O'Regan, Laura
Blot, Joelle
Fry, Andrew M
author_facet O'Regan, Laura
Blot, Joelle
Fry, Andrew M
author_sort O'Regan, Laura
collection PubMed
description The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast homologue Fin1, contribute to multiple aspects of mitotic progression including the timing of mitotic entry, chromatin condensation, spindle organization and cytokinesis. Mammals contain a large family of eleven NIMA-related kinases, named Nek1 to Nek11. Of these, there is now substantial evidence that Nek2, Nek6, Nek7 and Nek9 also regulate mitotic events. At least three of these kinases, as well as NIMA and Fin1, have been localized to the microtubule organizing centre of their respective species, namely the centrosome or spindle pole body. Here, they have important functions in microtubule organization and mitotic spindle assembly. Other Nek kinases have been proposed to play microtubule-dependent roles in non-dividing cells, most notably in regulating the axonemal microtubules of cilia and flagella. In this review, we discuss the evidence that NIMA-related kinases make a significant contribution to the orchestration of mitotic progression and thereby protect cells from chromosome instability. Furthermore, we highlight their potential as novel chemotherapeutic targets.
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spelling pubmed-20186892007-10-12 Mitotic regulation by NIMA-related kinases O'Regan, Laura Blot, Joelle Fry, Andrew M Cell Div Review The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast homologue Fin1, contribute to multiple aspects of mitotic progression including the timing of mitotic entry, chromatin condensation, spindle organization and cytokinesis. Mammals contain a large family of eleven NIMA-related kinases, named Nek1 to Nek11. Of these, there is now substantial evidence that Nek2, Nek6, Nek7 and Nek9 also regulate mitotic events. At least three of these kinases, as well as NIMA and Fin1, have been localized to the microtubule organizing centre of their respective species, namely the centrosome or spindle pole body. Here, they have important functions in microtubule organization and mitotic spindle assembly. Other Nek kinases have been proposed to play microtubule-dependent roles in non-dividing cells, most notably in regulating the axonemal microtubules of cilia and flagella. In this review, we discuss the evidence that NIMA-related kinases make a significant contribution to the orchestration of mitotic progression and thereby protect cells from chromosome instability. Furthermore, we highlight their potential as novel chemotherapeutic targets. BioMed Central 2007-08-29 /pmc/articles/PMC2018689/ /pubmed/17727698 http://dx.doi.org/10.1186/1747-1028-2-25 Text en Copyright © 2007 O'Regan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
O'Regan, Laura
Blot, Joelle
Fry, Andrew M
Mitotic regulation by NIMA-related kinases
title Mitotic regulation by NIMA-related kinases
title_full Mitotic regulation by NIMA-related kinases
title_fullStr Mitotic regulation by NIMA-related kinases
title_full_unstemmed Mitotic regulation by NIMA-related kinases
title_short Mitotic regulation by NIMA-related kinases
title_sort mitotic regulation by nima-related kinases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018689/
https://www.ncbi.nlm.nih.gov/pubmed/17727698
http://dx.doi.org/10.1186/1747-1028-2-25
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