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Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential

BACKGROUND: We have previously shown that prostate cancer LNCaP cells are resistant to TRAIL, and downregulation of PI-3K/Akt pathway by molecular and pharmacological means sensitizes cells to undergo apoptosis by TRAIL and curcumin. The purpose of this study was to examine the molecular mechanisms...

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Detalles Bibliográficos
Autores principales:	Shankar, Sharmila, Chen, Qinghe, Siddiqui, Imtiaz, Sarva, Krishna, Srivastava, Rakesh K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018690/ https://www.ncbi.nlm.nih.gov/pubmed/17718901 http://dx.doi.org/10.1186/1750-2187-2-7

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