The allosteric modulation of lipases and its possible biological relevance

BACKGROUND: During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown. THEORY: Considering the biological...

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Detalles Bibliográficos
Autores principales: Köhler, Jens, Wünsch, Bernhard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020465/
https://www.ncbi.nlm.nih.gov/pubmed/17825093
http://dx.doi.org/10.1186/1742-4682-4-34
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author Köhler, Jens
Wünsch, Bernhard
author_facet Köhler, Jens
Wünsch, Bernhard
author_sort Köhler, Jens
collection PubMed
description BACKGROUND: During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown. THEORY: Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism. CONCLUSION: This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.
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spelling pubmed-20204652007-10-13 The allosteric modulation of lipases and its possible biological relevance Köhler, Jens Wünsch, Bernhard Theor Biol Med Model Research BACKGROUND: During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown. THEORY: Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism. CONCLUSION: This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity. BioMed Central 2007-09-07 /pmc/articles/PMC2020465/ /pubmed/17825093 http://dx.doi.org/10.1186/1742-4682-4-34 Text en Copyright © 2007 Köhler and Wünsch; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Köhler, Jens
Wünsch, Bernhard
The allosteric modulation of lipases and its possible biological relevance
title The allosteric modulation of lipases and its possible biological relevance
title_full The allosteric modulation of lipases and its possible biological relevance
title_fullStr The allosteric modulation of lipases and its possible biological relevance
title_full_unstemmed The allosteric modulation of lipases and its possible biological relevance
title_short The allosteric modulation of lipases and its possible biological relevance
title_sort allosteric modulation of lipases and its possible biological relevance
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020465/
https://www.ncbi.nlm.nih.gov/pubmed/17825093
http://dx.doi.org/10.1186/1742-4682-4-34
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