The effect of anaesthetics on blood perfusion in transplanted mouse tumours.

Rubidium-86, 125I-human serum albumin and 51Cr-labelled red cells have been used to investigate the effects of the anaesthetics Nembutal (pentobarbitone sodium) and urethane on blood perfusion, blood volume and albumin leakage in 5 types of transplanted mouse tumour and in normal organs. Nembutal wa...

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Detalles Bibliográficos
Autores principales: Zanelli, G. D., Lucas, P. B., Fowler, J. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024746/
https://www.ncbi.nlm.nih.gov/pubmed/1233083
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author Zanelli, G. D.
Lucas, P. B.
Fowler, J. F.
author_facet Zanelli, G. D.
Lucas, P. B.
Fowler, J. F.
author_sort Zanelli, G. D.
collection PubMed
description Rubidium-86, 125I-human serum albumin and 51Cr-labelled red cells have been used to investigate the effects of the anaesthetics Nembutal (pentobarbitone sodium) and urethane on blood perfusion, blood volume and albumin leakage in 5 types of transplanted mouse tumour and in normal organs. Nembutal was found to increase the relative blood perfusion by a factor of 1-3 to 2-0 in tumours and by a factor of 1-7 to 3-0 in kidneys but muscle perfusion fell to 0-3-0-5 that of controls. The effects of urethane were found to be dose dependent, generally in the same direction as for Nembutal, and smaller. Both anaesthetics reduced the blood volume of tumours (except for the C3H mammary carcinoma) and of kidneys by factors of 0-2 to 0-8. The duration of anaesthesia had no effect on the plateau values of relative blood perfusion and blood volume in either tumours or normal organs, but Nembutal delayed slightly the 86Rb uptake and decreased the rate of albumin leakage.
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spelling pubmed-20247462009-09-10 The effect of anaesthetics on blood perfusion in transplanted mouse tumours. Zanelli, G. D. Lucas, P. B. Fowler, J. F. Br J Cancer Research Article Rubidium-86, 125I-human serum albumin and 51Cr-labelled red cells have been used to investigate the effects of the anaesthetics Nembutal (pentobarbitone sodium) and urethane on blood perfusion, blood volume and albumin leakage in 5 types of transplanted mouse tumour and in normal organs. Nembutal was found to increase the relative blood perfusion by a factor of 1-3 to 2-0 in tumours and by a factor of 1-7 to 3-0 in kidneys but muscle perfusion fell to 0-3-0-5 that of controls. The effects of urethane were found to be dose dependent, generally in the same direction as for Nembutal, and smaller. Both anaesthetics reduced the blood volume of tumours (except for the C3H mammary carcinoma) and of kidneys by factors of 0-2 to 0-8. The duration of anaesthesia had no effect on the plateau values of relative blood perfusion and blood volume in either tumours or normal organs, but Nembutal delayed slightly the 86Rb uptake and decreased the rate of albumin leakage. Nature Publishing Group 1975-09 /pmc/articles/PMC2024746/ /pubmed/1233083 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Zanelli, G. D.
Lucas, P. B.
Fowler, J. F.
The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title_full The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title_fullStr The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title_full_unstemmed The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title_short The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
title_sort effect of anaesthetics on blood perfusion in transplanted mouse tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024746/
https://www.ncbi.nlm.nih.gov/pubmed/1233083
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