Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.

The reactivity of lymphocytes from patients with either carcinoma of the breast or large bowel has been studied using the human to mouse normal lymphocyte transfer (NLT) reaction. It was found that, in the case of breast cancer, there was a direct correlation between the clinical stage and a reduced...

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Autores principales: Miller, J. J., Gaffney, P. R., Rees, J. A., Symes, M. O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024784/
https://www.ncbi.nlm.nih.gov/pubmed/1236735
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author Miller, J. J.
Gaffney, P. R.
Rees, J. A.
Symes, M. O.
author_facet Miller, J. J.
Gaffney, P. R.
Rees, J. A.
Symes, M. O.
author_sort Miller, J. J.
collection PubMed
description The reactivity of lymphocytes from patients with either carcinoma of the breast or large bowel has been studied using the human to mouse normal lymphocyte transfer (NLT) reaction. It was found that, in the case of breast cancer, there was a direct correlation between the clinical stage and a reduced NLT reaction. Only patients with regional lymph node or generalized metastases showed significantly reduced lymphocyte reactivity. However, in the case of large bowel cancer there was a generalized reduction in NLT reactivity which was independent of the clinical stage. Incubation of lymphocytes from individuals without neoplastic disease in serum or plasma from breast cancer patients, showing reduced NLT reactivity, resulted in a reduced NLT reaction. This appears to be indicative of the presence of circulating "blocking factor" in such patients.
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spelling pubmed-20247842009-09-10 Lymphocyte reactivity in patients with carcinoma of the breast and large bowel. Miller, J. J. Gaffney, P. R. Rees, J. A. Symes, M. O. Br J Cancer Research Article The reactivity of lymphocytes from patients with either carcinoma of the breast or large bowel has been studied using the human to mouse normal lymphocyte transfer (NLT) reaction. It was found that, in the case of breast cancer, there was a direct correlation between the clinical stage and a reduced NLT reaction. Only patients with regional lymph node or generalized metastases showed significantly reduced lymphocyte reactivity. However, in the case of large bowel cancer there was a generalized reduction in NLT reactivity which was independent of the clinical stage. Incubation of lymphocytes from individuals without neoplastic disease in serum or plasma from breast cancer patients, showing reduced NLT reactivity, resulted in a reduced NLT reaction. This appears to be indicative of the presence of circulating "blocking factor" in such patients. Nature Publishing Group 1975-07 /pmc/articles/PMC2024784/ /pubmed/1236735 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Miller, J. J.
Gaffney, P. R.
Rees, J. A.
Symes, M. O.
Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title_full Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title_fullStr Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title_full_unstemmed Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title_short Lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
title_sort lymphocyte reactivity in patients with carcinoma of the breast and large bowel.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024784/
https://www.ncbi.nlm.nih.gov/pubmed/1236735
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AT reesja lymphocytereactivityinpatientswithcarcinomaofthebreastandlargebowel
AT symesmo lymphocytereactivityinpatientswithcarcinomaofthebreastandlargebowel

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