A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.

Twenty-seven patients with malignant neoplasia were injected intradermally with the methanol extraction residue (MER) fraction of tubercle bacilli. Two schedules of treatment were used: every other week and once a month; 1-10 courses of MER were administered to the patients. The skin reactivity to 3...

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Detalles Bibliográficos
Autores principales: Robinson, E., Bartal, A., Cohen, Y., Haasz, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024786/
https://www.ncbi.nlm.nih.gov/pubmed/1100088
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author Robinson, E.
Bartal, A.
Cohen, Y.
Haasz, R.
author_facet Robinson, E.
Bartal, A.
Cohen, Y.
Haasz, R.
author_sort Robinson, E.
collection PubMed
description Twenty-seven patients with malignant neoplasia were injected intradermally with the methanol extraction residue (MER) fraction of tubercle bacilli. Two schedules of treatment were used: every other week and once a month; 1-10 courses of MER were administered to the patients. The skin reactivity to 3 recall antigens, as well as to the injected MER itself, was used to monitor the immune response. Improvement of skin reactivity occurred in 9 of 18 patients tested with recall antigens. Five of 6 patients treated every other week improved in their immune capacity whereas only 4 of 12 patients improved on the monthly schedule. Thus, repeated injections given every other week were more effective in increasing the cutaneous reactivity than monthly injections of MER. The side-effects of MER treatment were tolerable.
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spelling pubmed-20247862009-09-10 A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients. Robinson, E. Bartal, A. Cohen, Y. Haasz, R. Br J Cancer Research Article Twenty-seven patients with malignant neoplasia were injected intradermally with the methanol extraction residue (MER) fraction of tubercle bacilli. Two schedules of treatment were used: every other week and once a month; 1-10 courses of MER were administered to the patients. The skin reactivity to 3 recall antigens, as well as to the injected MER itself, was used to monitor the immune response. Improvement of skin reactivity occurred in 9 of 18 patients tested with recall antigens. Five of 6 patients treated every other week improved in their immune capacity whereas only 4 of 12 patients improved on the monthly schedule. Thus, repeated injections given every other week were more effective in increasing the cutaneous reactivity than monthly injections of MER. The side-effects of MER treatment were tolerable. Nature Publishing Group 1975-07 /pmc/articles/PMC2024786/ /pubmed/1100088 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Robinson, E.
Bartal, A.
Cohen, Y.
Haasz, R.
A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title_full A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title_fullStr A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title_full_unstemmed A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title_short A preliminary report on the effects of methanol extraction residue of BCG (MER) on cancer patients.
title_sort preliminary report on the effects of methanol extraction residue of bcg (mer) on cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024786/
https://www.ncbi.nlm.nih.gov/pubmed/1100088
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