Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.

Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplan...

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Detalles Bibliográficos
Autores principales: Woodruff, M. F., Dunbar, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024788/
https://www.ncbi.nlm.nih.gov/pubmed/1080671
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author Woodruff, M. F.
Dunbar, N.
author_facet Woodruff, M. F.
Dunbar, N.
author_sort Woodruff, M. F.
collection PubMed
description Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact CBA mice but has little or no effect on subcutaneous transplants of the same tumour in T-cell deprived mice. The anti-tumour effect of local injection of C. parvum, unlike that of systemic injection in this particular tumour system, thus appears to be T-cell dependent.
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spelling pubmed-20247882009-09-10 Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma. Woodruff, M. F. Dunbar, N. Br J Cancer Research Article Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact CBA mice but has little or no effect on subcutaneous transplants of the same tumour in T-cell deprived mice. The anti-tumour effect of local injection of C. parvum, unlike that of systemic injection in this particular tumour system, thus appears to be T-cell dependent. Nature Publishing Group 1975-07 /pmc/articles/PMC2024788/ /pubmed/1080671 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Woodruff, M. F.
Dunbar, N.
Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title_full Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title_fullStr Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title_full_unstemmed Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title_short Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma.
title_sort effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024788/
https://www.ncbi.nlm.nih.gov/pubmed/1080671
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