Granulocyte function in myeloblastic leukaemia.

A study of granulocyte function in myeloblastic leukaemia is reported. Function was assessed by the ability of peripheral blood granulocytes to ingest and kill Candida albicans in bitro. Depressed cidal activity was observed in 11 patients with smouldering leukaemia and in 19 patients with acute mye...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilkinson, P. M., Sumner, C., Delamore, I. W., Geary, C. G., Milner, G. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024806/
https://www.ncbi.nlm.nih.gov/pubmed/764849
_version_ 1782136633530777600
author Wilkinson, P. M.
Sumner, C.
Delamore, I. W.
Geary, C. G.
Milner, G. R.
author_facet Wilkinson, P. M.
Sumner, C.
Delamore, I. W.
Geary, C. G.
Milner, G. R.
author_sort Wilkinson, P. M.
collection PubMed
description A study of granulocyte function in myeloblastic leukaemia is reported. Function was assessed by the ability of peripheral blood granulocytes to ingest and kill Candida albicans in bitro. Depressed cidal activity was observed in 11 patients with smouldering leukaemia and in 19 patients with acute myeloid leukaemia. Cidal activity was lowest in the untreated acute disease; this improved during cytoreduction therapy and was maintained when remission occurred. Leukaemic plasma depressed the function of control granulocytes; the possible role of a plasma "factor" is discussed.
format Text
id pubmed-2024806
institution National Center for Biotechnology Information
language English
publishDate 1975
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20248062009-09-10 Granulocyte function in myeloblastic leukaemia. Wilkinson, P. M. Sumner, C. Delamore, I. W. Geary, C. G. Milner, G. R. Br J Cancer Research Article A study of granulocyte function in myeloblastic leukaemia is reported. Function was assessed by the ability of peripheral blood granulocytes to ingest and kill Candida albicans in bitro. Depressed cidal activity was observed in 11 patients with smouldering leukaemia and in 19 patients with acute myeloid leukaemia. Cidal activity was lowest in the untreated acute disease; this improved during cytoreduction therapy and was maintained when remission occurred. Leukaemic plasma depressed the function of control granulocytes; the possible role of a plasma "factor" is discussed. Nature Publishing Group 1975-11 /pmc/articles/PMC2024806/ /pubmed/764849 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wilkinson, P. M.
Sumner, C.
Delamore, I. W.
Geary, C. G.
Milner, G. R.
Granulocyte function in myeloblastic leukaemia.
title Granulocyte function in myeloblastic leukaemia.
title_full Granulocyte function in myeloblastic leukaemia.
title_fullStr Granulocyte function in myeloblastic leukaemia.
title_full_unstemmed Granulocyte function in myeloblastic leukaemia.
title_short Granulocyte function in myeloblastic leukaemia.
title_sort granulocyte function in myeloblastic leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024806/
https://www.ncbi.nlm.nih.gov/pubmed/764849
work_keys_str_mv AT wilkinsonpm granulocytefunctioninmyeloblasticleukaemia
AT sumnerc granulocytefunctioninmyeloblasticleukaemia
AT delamoreiw granulocytefunctioninmyeloblasticleukaemia
AT gearycg granulocytefunctioninmyeloblasticleukaemia
AT milnergr granulocytefunctioninmyeloblasticleukaemia

Ejemplares similares