The leucocyte adherence inhibtion test in cancer of the large bowel.

A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their...

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Detalles Bibliográficos
Autores principales: Armitstead, P. R., Gowland, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024808/
https://www.ncbi.nlm.nih.gov/pubmed/174707
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author Armitstead, P. R.
Gowland, G.
author_facet Armitstead, P. R.
Gowland, G.
author_sort Armitstead, P. R.
collection PubMed
description A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their separated peripheral leucocytes were tested in homologous AB serum. In autologous serum only 7/27 had significant reactivity; 6/20 patients with a variety of other malignancies showed sensitization to the colorectal antigen preparation. It is concluded that the leucocyte adherence inhibiton test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer.
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spelling pubmed-20248082009-09-10 The leucocyte adherence inhibtion test in cancer of the large bowel. Armitstead, P. R. Gowland, G. Br J Cancer Research Article A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their separated peripheral leucocytes were tested in homologous AB serum. In autologous serum only 7/27 had significant reactivity; 6/20 patients with a variety of other malignancies showed sensitization to the colorectal antigen preparation. It is concluded that the leucocyte adherence inhibiton test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer. Nature Publishing Group 1975-11 /pmc/articles/PMC2024808/ /pubmed/174707 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Armitstead, P. R.
Gowland, G.
The leucocyte adherence inhibtion test in cancer of the large bowel.
title The leucocyte adherence inhibtion test in cancer of the large bowel.
title_full The leucocyte adherence inhibtion test in cancer of the large bowel.
title_fullStr The leucocyte adherence inhibtion test in cancer of the large bowel.
title_full_unstemmed The leucocyte adherence inhibtion test in cancer of the large bowel.
title_short The leucocyte adherence inhibtion test in cancer of the large bowel.
title_sort leucocyte adherence inhibtion test in cancer of the large bowel.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024808/
https://www.ncbi.nlm.nih.gov/pubmed/174707
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