Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.

Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor whic...

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Detalles Bibliográficos
Autores principales: Millar, J. L., Hudspith, B. N., Blackett, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024837/
https://www.ncbi.nlm.nih.gov/pubmed/764844
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author Millar, J. L.
Hudspith, B. N.
Blackett, N. M.
author_facet Millar, J. L.
Hudspith, B. N.
Blackett, N. M.
author_sort Millar, J. L.
collection PubMed
description Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.
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spelling pubmed-20248372009-09-10 Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan. Millar, J. L. Hudspith, B. N. Blackett, N. M. Br J Cancer Research Article Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery. Nature Publishing Group 1975-08 /pmc/articles/PMC2024837/ /pubmed/764844 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Millar, J. L.
Hudspith, B. N.
Blackett, N. M.
Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title_full Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title_fullStr Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title_full_unstemmed Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title_short Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
title_sort reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024837/
https://www.ncbi.nlm.nih.gov/pubmed/764844
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