The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.

The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When me...

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Detalles Bibliográficos
Autor principal: Shewell, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024931/
https://www.ncbi.nlm.nih.gov/pubmed/1083245
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author Shewell, J.
author_facet Shewell, J.
author_sort Shewell, J.
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description The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When methotrexate is injected into the tumour a dose-dependent tumour response is obtained. Systemic citrovorum "rescue" prevents methotrexate lethalities but reduces tumour response by a factor of 2. Methotrexate-treated tumours have an increased volume doubling time post treatment.
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spelling pubmed-20249312009-09-10 The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice. Shewell, J. Br J Cancer Research Article The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When methotrexate is injected into the tumour a dose-dependent tumour response is obtained. Systemic citrovorum "rescue" prevents methotrexate lethalities but reduces tumour response by a factor of 2. Methotrexate-treated tumours have an increased volume doubling time post treatment. Nature Publishing Group 1976-02 /pmc/articles/PMC2024931/ /pubmed/1083245 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shewell, J.
The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title_full The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title_fullStr The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title_full_unstemmed The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title_short The effect of methotrexate on spontaneous mammary adenocarcinomata in female C3H mice.
title_sort effect of methotrexate on spontaneous mammary adenocarcinomata in female c3h mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024931/
https://www.ncbi.nlm.nih.gov/pubmed/1083245
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