The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.

The growth pattern and morphology of two transplantable acute leukaemias which arose spontaneously in pure line rats are described. They differ morphologically and on the basis of their behaviour in vivo, such as infiltration of lymphoid organs and presence in thoracic duct lymph, the leukaemia syng...

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Autor principal: Wrathmell, A. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024943/
https://www.ncbi.nlm.nih.gov/pubmed/1259914
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author Wrathmell, A. B.
author_facet Wrathmell, A. B.
author_sort Wrathmell, A. B.
collection PubMed
description The growth pattern and morphology of two transplantable acute leukaemias which arose spontaneously in pure line rats are described. They differ morphologically and on the basis of their behaviour in vivo, such as infiltration of lymphoid organs and presence in thoracic duct lymph, the leukaemia syngeneic to the August strain (referred to as the SAL) appears to be of myeloid type whereas the leukaemia syngeneic to the Hooded strain (referred to as the HRL) resembles acute lymphoblastic leukaemia. The HRL cells, but not the SAL cells, are lysed by murine anti-theta serum plus complement. These two transplantable acute leukaemias appear to be useful animal counterparts ot the human acute leukaemias and may be valuable models for studies on chemotherapy and immunotherapy. IMAGES:
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spelling pubmed-20249432009-09-10 The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats. Wrathmell, A. B. Br J Cancer Research Article The growth pattern and morphology of two transplantable acute leukaemias which arose spontaneously in pure line rats are described. They differ morphologically and on the basis of their behaviour in vivo, such as infiltration of lymphoid organs and presence in thoracic duct lymph, the leukaemia syngeneic to the August strain (referred to as the SAL) appears to be of myeloid type whereas the leukaemia syngeneic to the Hooded strain (referred to as the HRL) resembles acute lymphoblastic leukaemia. The HRL cells, but not the SAL cells, are lysed by murine anti-theta serum plus complement. These two transplantable acute leukaemias appear to be useful animal counterparts ot the human acute leukaemias and may be valuable models for studies on chemotherapy and immunotherapy. IMAGES: Nature Publishing Group 1976-02 /pmc/articles/PMC2024943/ /pubmed/1259914 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wrathmell, A. B.
The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title_full The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title_fullStr The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title_full_unstemmed The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title_short The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
title_sort growth patterns of two transplantable acute leukaemias of spontaneous origin in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024943/
https://www.ncbi.nlm.nih.gov/pubmed/1259914
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