Immunogenicity of a rat leukaemia of spontaneous origin (SAL).

The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoa...

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Autores principales: Wrathmell, A. B., Alexander, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024946/
https://www.ncbi.nlm.nih.gov/pubmed/769814
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author Wrathmell, A. B.
Alexander, P.
author_facet Wrathmell, A. B.
Alexander, P.
author_sort Wrathmell, A. B.
collection PubMed
description The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. However, immunization with SAL cells exposed to low doses of mitomycin-C slowed the growth of the challenge inoculum. Cells treated with high doses of mitomycin-C did not immunize. The results are interpreted in terms of rapid shedding of a tumour-specific antigen from the membrane of SAL cells.
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spelling pubmed-20249462009-09-10 Immunogenicity of a rat leukaemia of spontaneous origin (SAL). Wrathmell, A. B. Alexander, P. Br J Cancer Research Article The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. However, immunization with SAL cells exposed to low doses of mitomycin-C slowed the growth of the challenge inoculum. Cells treated with high doses of mitomycin-C did not immunize. The results are interpreted in terms of rapid shedding of a tumour-specific antigen from the membrane of SAL cells. Nature Publishing Group 1976-02 /pmc/articles/PMC2024946/ /pubmed/769814 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wrathmell, A. B.
Alexander, P.
Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title_full Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title_fullStr Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title_full_unstemmed Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title_short Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
title_sort immunogenicity of a rat leukaemia of spontaneous origin (sal).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024946/
https://www.ncbi.nlm.nih.gov/pubmed/769814
work_keys_str_mv AT wrathmellab immunogenicityofaratleukaemiaofspontaneousoriginsal
AT alexanderp immunogenicityofaratleukaemiaofspontaneousoriginsal

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