Effect of aprotinin on immunological resistance in tumour-bearing animals.

Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than...

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Detalles Bibliográficos
Autores principales: Latner, A. L., Turner, G. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024953/
https://www.ncbi.nlm.nih.gov/pubmed/1084153
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author Latner, A. L.
Turner, G. A.
author_facet Latner, A. L.
Turner, G. A.
author_sort Latner, A. L.
collection PubMed
description Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this effect. Pretreatment of non-cancerous mice with cortisone nullified the effectiveness of aprotinin in inhibiting the growth of a subsequent tumour graft. These results are interpreted as additional evidence that aprotinin enhances the immunological system against tumour cells.
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spelling pubmed-20249532009-09-10 Effect of aprotinin on immunological resistance in tumour-bearing animals. Latner, A. L. Turner, G. A. Br J Cancer Research Article Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this effect. Pretreatment of non-cancerous mice with cortisone nullified the effectiveness of aprotinin in inhibiting the growth of a subsequent tumour graft. These results are interpreted as additional evidence that aprotinin enhances the immunological system against tumour cells. Nature Publishing Group 1976-05 /pmc/articles/PMC2024953/ /pubmed/1084153 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Latner, A. L.
Turner, G. A.
Effect of aprotinin on immunological resistance in tumour-bearing animals.
title Effect of aprotinin on immunological resistance in tumour-bearing animals.
title_full Effect of aprotinin on immunological resistance in tumour-bearing animals.
title_fullStr Effect of aprotinin on immunological resistance in tumour-bearing animals.
title_full_unstemmed Effect of aprotinin on immunological resistance in tumour-bearing animals.
title_short Effect of aprotinin on immunological resistance in tumour-bearing animals.
title_sort effect of aprotinin on immunological resistance in tumour-bearing animals.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024953/
https://www.ncbi.nlm.nih.gov/pubmed/1084153
work_keys_str_mv AT latneral effectofaprotininonimmunologicalresistanceintumourbearinganimals
AT turnerga effectofaprotininonimmunologicalresistanceintumourbearinganimals

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