Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.

Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently fou...

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Autores principales: Meier, J., Coleman, M. S., Hutton, J. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024973/
https://www.ncbi.nlm.nih.gov/pubmed/1063590
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author Meier, J.
Coleman, M. S.
Hutton, J. J.
author_facet Meier, J.
Coleman, M. S.
Hutton, J. J.
author_sort Meier, J.
collection PubMed
description Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myeloma, untreated lymphoma and leukaemic reticuloendotheliosis. High values were observed in lymphocytes from patients with lymphoma during intensive combination chemotherapy. ADA levels in lymphocytes were not correlated with levels in granulocytes or erythrocytes. ADA was elevated in blasts of patients with acute lymphocytic and myelogenous leukaemias but the ranges of activities per cell were so similar that ADA assay is unlikely to be of major help in distinguishing the two diseases.
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spelling pubmed-20249732009-09-10 Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies. Meier, J. Coleman, M. S. Hutton, J. J. Br J Cancer Research Article Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myeloma, untreated lymphoma and leukaemic reticuloendotheliosis. High values were observed in lymphocytes from patients with lymphoma during intensive combination chemotherapy. ADA levels in lymphocytes were not correlated with levels in granulocytes or erythrocytes. ADA was elevated in blasts of patients with acute lymphocytic and myelogenous leukaemias but the ranges of activities per cell were so similar that ADA assay is unlikely to be of major help in distinguishing the two diseases. Nature Publishing Group 1976-03 /pmc/articles/PMC2024973/ /pubmed/1063590 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Meier, J.
Coleman, M. S.
Hutton, J. J.
Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title_full Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title_fullStr Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title_full_unstemmed Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title_short Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
title_sort adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024973/
https://www.ncbi.nlm.nih.gov/pubmed/1063590
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AT huttonjj adenosinedeaminaseactivityinperipheralbloodcellsofpatientswithhaematologicalmalignancies

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