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Structure-activity relationships in nitrosamine carcinogenesis.
Statistically significant correlations have been demonstrated between carcinogenic activity, toxicity and number of carbons per molecule for an extensive set of nitrosamines. Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1976
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024977/ https://www.ncbi.nlm.nih.gov/pubmed/942605 |
| _version_ | 1782136669941530624 |
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| author | Wishnok, J. S. Archer, M. C. |
| author_facet | Wishnok, J. S. Archer, M. C. |
| author_sort | Wishnok, J. S. |
| collection | PubMed |
| description | Statistically significant correlations have been demonstrated between carcinogenic activity, toxicity and number of carbons per molecule for an extensive set of nitrosamines. Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need not be the sole determinants of carcinogenic activity. These structure-activity relationships can be used to estimate carcinogenic activity with some degree of confidence. |
| format | Text |
| id | pubmed-2024977 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1976 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-20249772009-09-10 Structure-activity relationships in nitrosamine carcinogenesis. Wishnok, J. S. Archer, M. C. Br J Cancer Research Article Statistically significant correlations have been demonstrated between carcinogenic activity, toxicity and number of carbons per molecule for an extensive set of nitrosamines. Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need not be the sole determinants of carcinogenic activity. These structure-activity relationships can be used to estimate carcinogenic activity with some degree of confidence. Nature Publishing Group 1976-03 /pmc/articles/PMC2024977/ /pubmed/942605 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Wishnok, J. S. Archer, M. C. Structure-activity relationships in nitrosamine carcinogenesis. |
| title | Structure-activity relationships in nitrosamine carcinogenesis. |
| title_full | Structure-activity relationships in nitrosamine carcinogenesis. |
| title_fullStr | Structure-activity relationships in nitrosamine carcinogenesis. |
| title_full_unstemmed | Structure-activity relationships in nitrosamine carcinogenesis. |
| title_short | Structure-activity relationships in nitrosamine carcinogenesis. |
| title_sort | structure-activity relationships in nitrosamine carcinogenesis. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024977/ https://www.ncbi.nlm.nih.gov/pubmed/942605 |
| work_keys_str_mv | AT wishnokjs structureactivityrelationshipsinnitrosaminecarcinogenesis AT archermc structureactivityrelationshipsinnitrosaminecarcinogenesis |