Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.

A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into pla...

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Detalles Bibliográficos
Autores principales: Balkwill, F. R., Oliver, R. T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025083/
https://www.ncbi.nlm.nih.gov/pubmed/1063591
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author Balkwill, F. R.
Oliver, R. T.
author_facet Balkwill, F. R.
Oliver, R. T.
author_sort Balkwill, F. R.
collection PubMed
description A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for "differentiation" have a better chance of achieving complete remission. IMAGES:
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spelling pubmed-20250832009-09-10 Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia. Balkwill, F. R. Oliver, R. T. Br J Cancer Research Article A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for "differentiation" have a better chance of achieving complete remission. IMAGES: Nature Publishing Group 1976-04 /pmc/articles/PMC2025083/ /pubmed/1063591 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Balkwill, F. R.
Oliver, R. T.
Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title_full Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title_fullStr Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title_full_unstemmed Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title_short Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
title_sort diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025083/
https://www.ncbi.nlm.nih.gov/pubmed/1063591
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