The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.

The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early plat...

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Autor principal: Twentyman, P. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025089/
https://www.ncbi.nlm.nih.gov/pubmed/57791
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author Twentyman, P. R.
author_facet Twentyman, P. R.
author_sort Twentyman, P. R.
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description The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early plateau phases of growth, but little potentiation occurs in late plateau phase. The effect of exposing the cells to the two drugs consecutively in either order is greater than if the two agents are used at the same time. In vivo, it does not appear that pentamycin can greatly increase the cytocidal effect of bleomycin.
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spelling pubmed-20250892009-09-10 The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo. Twentyman, P. R. Br J Cancer Research Article The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early plateau phases of growth, but little potentiation occurs in late plateau phase. The effect of exposing the cells to the two drugs consecutively in either order is greater than if the two agents are used at the same time. In vivo, it does not appear that pentamycin can greatly increase the cytocidal effect of bleomycin. Nature Publishing Group 1976-04 /pmc/articles/PMC2025089/ /pubmed/57791 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Twentyman, P. R.
The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title_full The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title_fullStr The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title_full_unstemmed The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title_short The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
title_sort effect of bleomycin and pentamycin in combination on the survival of emt6 mouse tumour cells in vitro and in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025089/
https://www.ncbi.nlm.nih.gov/pubmed/57791
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