Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.

The weights of osteosarcomata that arose 22 days after the s.c. injection of cell suspensions (of whold tumours) that had been exposed in vitro to tRNA were significantly different from the weights of those arising from untreated cells. The tRNA was isolated by phenol extraction and DEAE-cellulose c...

Descripción completa

Detalles Bibliográficos
Autores principales: Geddes-Dwyer, V., Cameron, D. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025107/
https://www.ncbi.nlm.nih.gov/pubmed/1065354
_version_ 1782136698088456192
author Geddes-Dwyer, V.
Cameron, D. A.
author_facet Geddes-Dwyer, V.
Cameron, D. A.
author_sort Geddes-Dwyer, V.
collection PubMed
description The weights of osteosarcomata that arose 22 days after the s.c. injection of cell suspensions (of whold tumours) that had been exposed in vitro to tRNA were significantly different from the weights of those arising from untreated cells. The tRNA was isolated by phenol extraction and DEAE-cellulose chromatography from eviscerated full-term rat embryos, from rat mesenchymal (granulation) tissue and from rat anaplastic osteosarcomata. Tumours developing from osteosarcoma cells treated with either embryonic or normal mesenchymal tRNA were reduced in weight by 76% and 60% respectively. These effects could not be explained as a toxic consequence, because tumour weight was increased by 128% after exposure of cells to osteosarcoma tRNA. In this osteosarcoma model it appears that tumour weights can be influenced in different ways by tRNA from different sources.
format Text
id pubmed-2025107
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20251072009-09-10 Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata. Geddes-Dwyer, V. Cameron, D. A. Br J Cancer Research Article The weights of osteosarcomata that arose 22 days after the s.c. injection of cell suspensions (of whold tumours) that had been exposed in vitro to tRNA were significantly different from the weights of those arising from untreated cells. The tRNA was isolated by phenol extraction and DEAE-cellulose chromatography from eviscerated full-term rat embryos, from rat mesenchymal (granulation) tissue and from rat anaplastic osteosarcomata. Tumours developing from osteosarcoma cells treated with either embryonic or normal mesenchymal tRNA were reduced in weight by 76% and 60% respectively. These effects could not be explained as a toxic consequence, because tumour weight was increased by 128% after exposure of cells to osteosarcoma tRNA. In this osteosarcoma model it appears that tumour weights can be influenced in different ways by tRNA from different sources. Nature Publishing Group 1976-06 /pmc/articles/PMC2025107/ /pubmed/1065354 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Geddes-Dwyer, V.
Cameron, D. A.
Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title_full Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title_fullStr Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title_full_unstemmed Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title_short Influence of exogenous tRNA on growth of transplantable 32P-induced osteosarcomata.
title_sort influence of exogenous trna on growth of transplantable 32p-induced osteosarcomata.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025107/
https://www.ncbi.nlm.nih.gov/pubmed/1065354
work_keys_str_mv AT geddesdwyerv influenceofexogenoustrnaongrowthoftransplantable32pinducedosteosarcomata
AT cameronda influenceofexogenoustrnaongrowthoftransplantable32pinducedosteosarcomata

Ejemplares similares