Ovarian failure following abdominal irradiation in childhood.

Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian fai...

Descripción completa

Detalles Bibliográficos
Autores principales: Shalet, S. M., Beardwell, C. G., Jones, P. H., Pearson, D., Orrell, D. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025110/
https://www.ncbi.nlm.nih.gov/pubmed/938613
_version_ 1782136698795196416
author Shalet, S. M.
Beardwell, C. G.
Jones, P. H.
Pearson, D.
Orrell, D. H.
author_facet Shalet, S. M.
Beardwell, C. G.
Jones, P. H.
Pearson, D.
Orrell, D. H.
author_sort Shalet, S. M.
collection PubMed
description Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.
format Text
id pubmed-2025110
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20251102009-09-10 Ovarian failure following abdominal irradiation in childhood. Shalet, S. M. Beardwell, C. G. Jones, P. H. Pearson, D. Orrell, D. H. Br J Cancer Research Article Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16. Nature Publishing Group 1976-06 /pmc/articles/PMC2025110/ /pubmed/938613 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shalet, S. M.
Beardwell, C. G.
Jones, P. H.
Pearson, D.
Orrell, D. H.
Ovarian failure following abdominal irradiation in childhood.
title Ovarian failure following abdominal irradiation in childhood.
title_full Ovarian failure following abdominal irradiation in childhood.
title_fullStr Ovarian failure following abdominal irradiation in childhood.
title_full_unstemmed Ovarian failure following abdominal irradiation in childhood.
title_short Ovarian failure following abdominal irradiation in childhood.
title_sort ovarian failure following abdominal irradiation in childhood.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025110/
https://www.ncbi.nlm.nih.gov/pubmed/938613
work_keys_str_mv AT shaletsm ovarianfailurefollowingabdominalirradiationinchildhood
AT beardwellcg ovarianfailurefollowingabdominalirradiationinchildhood
AT jonesph ovarianfailurefollowingabdominalirradiationinchildhood
AT pearsond ovarianfailurefollowingabdominalirradiationinchildhood
AT orrelldh ovarianfailurefollowingabdominalirradiationinchildhood

Ejemplares similares