The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.

Newborn A, C57BL, DBAf and IF mice were injected s.c. with a range of doses of N-ethyl-N-nitrosourea (ENU). A high proportion of treated mice developed tumours, particularly hepatomata, pulmonary adenomata and carcinomata, and malignant lymphomata of thymus and spleen. Liver tumours occurred most fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Searle, C. E., Jones, E. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025114/
https://www.ncbi.nlm.nih.gov/pubmed/938611
_version_ 1782136699487256576
author Searle, C. E.
Jones, E. L.
author_facet Searle, C. E.
Jones, E. L.
author_sort Searle, C. E.
collection PubMed
description Newborn A, C57BL, DBAf and IF mice were injected s.c. with a range of doses of N-ethyl-N-nitrosourea (ENU). A high proportion of treated mice developed tumours, particularly hepatomata, pulmonary adenomata and carcinomata, and malignant lymphomata of thymus and spleen. Liver tumours occurred most frequently in C57BL and DBAf mice, lung tumours in A mice, and lymphomata in A and DBAf mice. A small proportion of C57BL, DBAf and IF mice developed tumours of the nervous system. The results are discussed with reference to the ready induction of nervous system tumours in similarly treated rats, and their relevance for human cancer. IMAGES:
format Text
id pubmed-2025114
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20251142009-09-10 The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice. Searle, C. E. Jones, E. L. Br J Cancer Research Article Newborn A, C57BL, DBAf and IF mice were injected s.c. with a range of doses of N-ethyl-N-nitrosourea (ENU). A high proportion of treated mice developed tumours, particularly hepatomata, pulmonary adenomata and carcinomata, and malignant lymphomata of thymus and spleen. Liver tumours occurred most frequently in C57BL and DBAf mice, lung tumours in A mice, and lymphomata in A and DBAf mice. A small proportion of C57BL, DBAf and IF mice developed tumours of the nervous system. The results are discussed with reference to the ready induction of nervous system tumours in similarly treated rats, and their relevance for human cancer. IMAGES: Nature Publishing Group 1976-06 /pmc/articles/PMC2025114/ /pubmed/938611 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Searle, C. E.
Jones, E. L.
The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title_full The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title_fullStr The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title_full_unstemmed The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title_short The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
title_sort multipotential carcinogenic action of n-ethyl-n-nitrosourea administered neonatally to mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025114/
https://www.ncbi.nlm.nih.gov/pubmed/938611
work_keys_str_mv AT searlece themultipotentialcarcinogenicactionofnethylnnitrosoureaadministeredneonatallytomice
AT jonesel themultipotentialcarcinogenicactionofnethylnnitrosoureaadministeredneonatallytomice
AT searlece multipotentialcarcinogenicactionofnethylnnitrosoureaadministeredneonatallytomice
AT jonesel multipotentialcarcinogenicactionofnethylnnitrosoureaadministeredneonatallytomice

Ejemplares similares