Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.

Effects of neonatal androgenization or neonatal ovariectomy in female rats on endocrine functions and mammary tumourigenesis are examined. Pituitary gonadotrophin contents (both LH and FSH) are significantly lower in neonatally androgenized rats (TT) and significantly increased in neonatally ovariec...

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Autores principales: Christakos, S., Sinha, D., Dao, T. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025131/
https://www.ncbi.nlm.nih.gov/pubmed/821507
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author Christakos, S.
Sinha, D.
Dao, T. L.
author_facet Christakos, S.
Sinha, D.
Dao, T. L.
author_sort Christakos, S.
collection PubMed
description Effects of neonatal androgenization or neonatal ovariectomy in female rats on endocrine functions and mammary tumourigenesis are examined. Pituitary gonadotrophin contents (both LH and FSH) are significantly lower in neonatally androgenized rats (TT) and significantly increased in neonatally ovariectomized rats (NO) when compared with controls of the same age. Plasma and pituitary prolactin levels are higher in TT rats than in the control rats of the same age, but the difference is not significant. Mammary tumours developing in TT rats after DMBA treatment are predominantly fibroadenomata, and lactogenesis in TT rats occurs almost entirely in those receiving DMBA treatment. Neonatal ovariectomy in female rats protects against subsequent induction of mammary cnacer by DMBA. The relationship between neonatal modification of endocrine functions and mammary tumourigenesis is discussed.
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spelling pubmed-20251312009-09-10 Neonatal modification of endocrine functions and mammary carcinogenesis in the rat. Christakos, S. Sinha, D. Dao, T. L. Br J Cancer Research Article Effects of neonatal androgenization or neonatal ovariectomy in female rats on endocrine functions and mammary tumourigenesis are examined. Pituitary gonadotrophin contents (both LH and FSH) are significantly lower in neonatally androgenized rats (TT) and significantly increased in neonatally ovariectomized rats (NO) when compared with controls of the same age. Plasma and pituitary prolactin levels are higher in TT rats than in the control rats of the same age, but the difference is not significant. Mammary tumours developing in TT rats after DMBA treatment are predominantly fibroadenomata, and lactogenesis in TT rats occurs almost entirely in those receiving DMBA treatment. Neonatal ovariectomy in female rats protects against subsequent induction of mammary cnacer by DMBA. The relationship between neonatal modification of endocrine functions and mammary tumourigenesis is discussed. Nature Publishing Group 1976-07 /pmc/articles/PMC2025131/ /pubmed/821507 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Christakos, S.
Sinha, D.
Dao, T. L.
Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title_full Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title_fullStr Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title_full_unstemmed Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title_short Neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
title_sort neonatal modification of endocrine functions and mammary carcinogenesis in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025131/
https://www.ncbi.nlm.nih.gov/pubmed/821507
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