Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.

Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistan...

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Detalles Bibliográficos
Autores principales: Smith, B. J., Kundu, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025136/
https://www.ncbi.nlm.nih.gov/pubmed/1066148
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author Smith, B. J.
Kundu, D.
author_facet Smith, B. J.
Kundu, D.
author_sort Smith, B. J.
collection PubMed
description Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA.
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spelling pubmed-20251362009-09-10 Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia. Smith, B. J. Kundu, D. Br J Cancer Research Article Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could to some extent be overcome by conjugating daunorubicin to DNA. Nature Publishing Group 1976-07 /pmc/articles/PMC2025136/ /pubmed/1066148 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smith, B. J.
Kundu, D.
Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title_full Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title_fullStr Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title_full_unstemmed Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title_short Acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
title_sort acquired resistance to daunorubicin in a patient with acute myelogenous leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025136/
https://www.ncbi.nlm.nih.gov/pubmed/1066148
work_keys_str_mv AT smithbj acquiredresistancetodaunorubicininapatientwithacutemyelogenousleukaemia
AT kundud acquiredresistancetodaunorubicininapatientwithacutemyelogenousleukaemia

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