Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.

Human bone marrow obtained from patients with neutropenia contains a cell population which is absent or diminished in normal marrow. The abnormal population is composed of cells of volume 200-300 mum3 which sediment at 5-5 to 8-5 mm/h. Normal marrow contains one cell class giving rise to increased n...

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Autores principales: Wiseman, L. L., Senn, J. S., Miller, R. G., Price, G. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025141/
https://www.ncbi.nlm.nih.gov/pubmed/952714
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author Wiseman, L. L.
Senn, J. S.
Miller, R. G.
Price, G. B.
author_facet Wiseman, L. L.
Senn, J. S.
Miller, R. G.
Price, G. B.
author_sort Wiseman, L. L.
collection PubMed
description Human bone marrow obtained from patients with neutropenia contains a cell population which is absent or diminished in normal marrow. The abnormal population is composed of cells of volume 200-300 mum3 which sediment at 5-5 to 8-5 mm/h. Normal marrow contains one cell class giving rise to increased numbers of grnaulocyte colonies after mass culture, while marrow obtained from neutropenic patients, or from patients with marrow regeneration, shows two such populations; one of these cell classes corresponds to the abnormally large cells demonstrated on velocity sedimentation analysis. This population of large cells may represent a group of either self-renewing cells related to the committed granulocyte progenitors or the pluripotent stem cell.
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spelling pubmed-20251412009-09-10 Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis. Wiseman, L. L. Senn, J. S. Miller, R. G. Price, G. B. Br J Cancer Research Article Human bone marrow obtained from patients with neutropenia contains a cell population which is absent or diminished in normal marrow. The abnormal population is composed of cells of volume 200-300 mum3 which sediment at 5-5 to 8-5 mm/h. Normal marrow contains one cell class giving rise to increased numbers of grnaulocyte colonies after mass culture, while marrow obtained from neutropenic patients, or from patients with marrow regeneration, shows two such populations; one of these cell classes corresponds to the abnormally large cells demonstrated on velocity sedimentation analysis. This population of large cells may represent a group of either self-renewing cells related to the committed granulocyte progenitors or the pluripotent stem cell. Nature Publishing Group 1976-07 /pmc/articles/PMC2025141/ /pubmed/952714 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wiseman, L. L.
Senn, J. S.
Miller, R. G.
Price, G. B.
Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title_full Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title_fullStr Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title_full_unstemmed Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title_short Stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
title_sort stem cell characterization of neutropenia: velocity sedimentation and mass culture analysis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025141/
https://www.ncbi.nlm.nih.gov/pubmed/952714
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