Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.

Fifty-six patients with disseminated malignant melanoma were randomly allocated to two treatment groups. The first group C received combination chemotherapy consisting of DTIC and ICRF 159. The second group (C+I) received the same chemotherapy but were also immunized with 2 X 10(7) irradiated alloge...

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Autores principales: Newlands, E. S., Oon, C. J., Roberts, J. T., Elliott, P., Mould, R. F., Topham, C., Madden, F. J., Newton, K. A., Westbury, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025153/
https://www.ncbi.nlm.nih.gov/pubmed/962994
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author Newlands, E. S.
Oon, C. J.
Roberts, J. T.
Elliott, P.
Mould, R. F.
Topham, C.
Madden, F. J.
Newton, K. A.
Westbury, G.
author_facet Newlands, E. S.
Oon, C. J.
Roberts, J. T.
Elliott, P.
Mould, R. F.
Topham, C.
Madden, F. J.
Newton, K. A.
Westbury, G.
author_sort Newlands, E. S.
collection PubMed
description Fifty-six patients with disseminated malignant melanoma were randomly allocated to two treatment groups. The first group C received combination chemotherapy consisting of DTIC and ICRF 159. The second group (C+I) received the same chemotherapy but were also immunized with 2 X 10(7) irradiated allogeneic melanoma cells mixed with 50 mug of percutaneous BCG. The survival rates in both treatment groups C and (C+I) were not significantly different, and only minor enhancement of the chemotherapy was found in the (C+I) group. A similar pattern of tissue response was observed in both groups: lymph node, skin and, to some extent liver metastases, respond better than other sites.
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spelling pubmed-20251532009-09-10 Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma. Newlands, E. S. Oon, C. J. Roberts, J. T. Elliott, P. Mould, R. F. Topham, C. Madden, F. J. Newton, K. A. Westbury, G. Br J Cancer Research Article Fifty-six patients with disseminated malignant melanoma were randomly allocated to two treatment groups. The first group C received combination chemotherapy consisting of DTIC and ICRF 159. The second group (C+I) received the same chemotherapy but were also immunized with 2 X 10(7) irradiated allogeneic melanoma cells mixed with 50 mug of percutaneous BCG. The survival rates in both treatment groups C and (C+I) were not significantly different, and only minor enhancement of the chemotherapy was found in the (C+I) group. A similar pattern of tissue response was observed in both groups: lymph node, skin and, to some extent liver metastases, respond better than other sites. Nature Publishing Group 1976-08 /pmc/articles/PMC2025153/ /pubmed/962994 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Newlands, E. S.
Oon, C. J.
Roberts, J. T.
Elliott, P.
Mould, R. F.
Topham, C.
Madden, F. J.
Newton, K. A.
Westbury, G.
Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title_full Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title_fullStr Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title_full_unstemmed Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title_short Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
title_sort clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025153/
https://www.ncbi.nlm.nih.gov/pubmed/962994
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