Early responses to chemotherapy detected by pulse cytophotometry.

DNA/cell distributions were recorded by automated cytofluorometry (=pulse cytophotometry) in bone-marrow aspirates of leukaemia and lymphosarcoma patients subjected to chemotherapy. In most cases, early perturbations in DNA/cell histographs were observed, characteristically reflecting the known mode...

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Autores principales: Smets, L. A., Mulder, E., de Waal, F. C., Cleton, F. J., Blok, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025166/
https://www.ncbi.nlm.nih.gov/pubmed/989466
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author Smets, L. A.
Mulder, E.
de Waal, F. C.
Cleton, F. J.
Blok, J.
author_facet Smets, L. A.
Mulder, E.
de Waal, F. C.
Cleton, F. J.
Blok, J.
author_sort Smets, L. A.
collection PubMed
description DNA/cell distributions were recorded by automated cytofluorometry (=pulse cytophotometry) in bone-marrow aspirates of leukaemia and lymphosarcoma patients subjected to chemotherapy. In most cases, early perturbations in DNA/cell histographs were observed, characteristically reflecting the known mode of action of the drugs. These changes in general preceded the clinical observation of drug response. In a series of 23 measurements in 19 patients, a positive correlation between early cytophotometric changes and clinical effects of chemotherapy was observed in 17 patients. Five patients were negative for both cytophotometric and clinical reactions and one patient was probably false-positive. The validity of the assay for early detection of drug resistance in acute leukaemia and related diseases is discussed.
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spelling pubmed-20251662009-09-10 Early responses to chemotherapy detected by pulse cytophotometry. Smets, L. A. Mulder, E. de Waal, F. C. Cleton, F. J. Blok, J. Br J Cancer Research Article DNA/cell distributions were recorded by automated cytofluorometry (=pulse cytophotometry) in bone-marrow aspirates of leukaemia and lymphosarcoma patients subjected to chemotherapy. In most cases, early perturbations in DNA/cell histographs were observed, characteristically reflecting the known mode of action of the drugs. These changes in general preceded the clinical observation of drug response. In a series of 23 measurements in 19 patients, a positive correlation between early cytophotometric changes and clinical effects of chemotherapy was observed in 17 patients. Five patients were negative for both cytophotometric and clinical reactions and one patient was probably false-positive. The validity of the assay for early detection of drug resistance in acute leukaemia and related diseases is discussed. Nature Publishing Group 1976-08 /pmc/articles/PMC2025166/ /pubmed/989466 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smets, L. A.
Mulder, E.
de Waal, F. C.
Cleton, F. J.
Blok, J.
Early responses to chemotherapy detected by pulse cytophotometry.
title Early responses to chemotherapy detected by pulse cytophotometry.
title_full Early responses to chemotherapy detected by pulse cytophotometry.
title_fullStr Early responses to chemotherapy detected by pulse cytophotometry.
title_full_unstemmed Early responses to chemotherapy detected by pulse cytophotometry.
title_short Early responses to chemotherapy detected by pulse cytophotometry.
title_sort early responses to chemotherapy detected by pulse cytophotometry.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025166/
https://www.ncbi.nlm.nih.gov/pubmed/989466
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AT cletonfj earlyresponsestochemotherapydetectedbypulsecytophotometry
AT blokj earlyresponsestochemotherapydetectedbypulsecytophotometry

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