Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.

Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the...

Descripción completa

Detalles Bibliográficos
Autores principales: Giovarelli, M., Comoglio, P. M., Forni, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025188/
https://www.ncbi.nlm.nih.gov/pubmed/788762
_version_ 1782136714276372480
author Giovarelli, M.
Comoglio, P. M.
Forni, G.
author_facet Giovarelli, M.
Comoglio, P. M.
Forni, G.
author_sort Giovarelli, M.
collection PubMed
description Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth.
format Text
id pubmed-2025188
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20251882009-09-10 Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes. Giovarelli, M. Comoglio, P. M. Forni, G. Br J Cancer Research Article Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth. Nature Publishing Group 1976-09 /pmc/articles/PMC2025188/ /pubmed/788762 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Giovarelli, M.
Comoglio, P. M.
Forni, G.
Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title_full Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title_fullStr Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title_full_unstemmed Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title_short Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
title_sort induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025188/
https://www.ncbi.nlm.nih.gov/pubmed/788762
work_keys_str_mv AT giovarellim inductionofresistanceorenhancementtoatransplantablemurineplasmacytomabytransferofnonimmuneleucocytes
AT comogliopm inductionofresistanceorenhancementtoatransplantablemurineplasmacytomabytransferofnonimmuneleucocytes
AT fornig inductionofresistanceorenhancementtoatransplantablemurineplasmacytomabytransferofnonimmuneleucocytes

Ejemplares similares