Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.

The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implanta...

Descripción completa

Detalles Bibliográficos
Autores principales: Wainberg, M. A., Deutsch, V., Weiss, D. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025198/
https://www.ncbi.nlm.nih.gov/pubmed/187207
_version_ 1782136716149129216
author Wainberg, M. A.
Deutsch, V.
Weiss, D. W.
author_facet Wainberg, M. A.
Deutsch, V.
Weiss, D. W.
author_sort Wainberg, M. A.
collection PubMed
description The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.
format Text
id pubmed-2025198
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20251982009-09-10 Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG. Wainberg, M. A. Deutsch, V. Weiss, D. W. Br J Cancer Research Article The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis. Nature Publishing Group 1976-11 /pmc/articles/PMC2025198/ /pubmed/187207 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wainberg, M. A.
Deutsch, V.
Weiss, D. W.
Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title_full Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title_fullStr Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title_full_unstemmed Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title_short Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
title_sort stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of bcg.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025198/
https://www.ncbi.nlm.nih.gov/pubmed/187207
work_keys_str_mv AT wainbergma stimulationofantitumourimmunityinguineapigsbymethanolextractionresidueofbcg
AT deutschv stimulationofantitumourimmunityinguineapigsbymethanolextractionresidueofbcg
AT weissdw stimulationofantitumourimmunityinguineapigsbymethanolextractionresidueofbcg

Ejemplares similares