Cytolytic effects of the complement cleavage product, C3a.

Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferluga, J., Schorlemmer, H. U., Baptista, L. C., Allison, A. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025225/
https://www.ncbi.nlm.nih.gov/pubmed/827304
Descripción
Sumario:Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.

Ejemplares similares