Cytolytic effects of the complement cleavage product, C3a.

Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or...

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Detalles Bibliográficos
Autores principales: Ferluga, J., Schorlemmer, H. U., Baptista, L. C., Allison, A. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025225/
https://www.ncbi.nlm.nih.gov/pubmed/827304
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author Ferluga, J.
Schorlemmer, H. U.
Baptista, L. C.
Allison, A. C.
author_facet Ferluga, J.
Schorlemmer, H. U.
Baptista, L. C.
Allison, A. C.
author_sort Ferluga, J.
collection PubMed
description Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.
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spelling pubmed-20252252009-09-10 Cytolytic effects of the complement cleavage product, C3a. Ferluga, J. Schorlemmer, H. U. Baptista, L. C. Allison, A. C. Br J Cancer Research Article Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed. Nature Publishing Group 1976-12 /pmc/articles/PMC2025225/ /pubmed/827304 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ferluga, J.
Schorlemmer, H. U.
Baptista, L. C.
Allison, A. C.
Cytolytic effects of the complement cleavage product, C3a.
title Cytolytic effects of the complement cleavage product, C3a.
title_full Cytolytic effects of the complement cleavage product, C3a.
title_fullStr Cytolytic effects of the complement cleavage product, C3a.
title_full_unstemmed Cytolytic effects of the complement cleavage product, C3a.
title_short Cytolytic effects of the complement cleavage product, C3a.
title_sort cytolytic effects of the complement cleavage product, c3a.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025225/
https://www.ncbi.nlm.nih.gov/pubmed/827304
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AT allisonac cytolyticeffectsofthecomplementcleavageproductc3a

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