Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.

Canine melanoma has been transplanted to allogeneic neonatal recipients receiving continuous immunosuppression with anti-lymphocyte serum. One spontaneous melanoma was directly transplanted into 8 recipients, 6 of which developed tumours. 5/5 melanoma cell cultures were transplantable, with 19 tumou...

Descripción completa

Detalles Bibliográficos
Autores principales: Betton, G. R., Owen, L. N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1976
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025258/
https://www.ncbi.nlm.nih.gov/pubmed/974003
_version_ 1782136727853334528
author Betton, G. R.
Owen, L. N.
author_facet Betton, G. R.
Owen, L. N.
author_sort Betton, G. R.
collection PubMed
description Canine melanoma has been transplanted to allogeneic neonatal recipients receiving continuous immunosuppression with anti-lymphocyte serum. One spontaneous melanoma was directly transplanted into 8 recipients, 6 of which developed tumours. 5/5 melanoma cell cultures were transplantable, with 19 tumour takes in 31 allogeneic recipients. Serial passage was performed in the case of two melanomas. Tumour development required continuous immunosuppression and the site was dependent upon the route of inoculation and other factors. Transplanted cell cultures were all amelanotic in vitro and in vivo, except in the case of one melanoma which reverted to a melanotic morphology after in vivo growth. IMAGES:
format Text
id pubmed-2025258
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20252582009-09-10 Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs. Betton, G. R. Owen, L. N. Br J Cancer Research Article Canine melanoma has been transplanted to allogeneic neonatal recipients receiving continuous immunosuppression with anti-lymphocyte serum. One spontaneous melanoma was directly transplanted into 8 recipients, 6 of which developed tumours. 5/5 melanoma cell cultures were transplantable, with 19 tumour takes in 31 allogeneic recipients. Serial passage was performed in the case of two melanomas. Tumour development required continuous immunosuppression and the site was dependent upon the route of inoculation and other factors. Transplanted cell cultures were all amelanotic in vitro and in vivo, except in the case of one melanoma which reverted to a melanotic morphology after in vivo growth. IMAGES: Nature Publishing Group 1976-10 /pmc/articles/PMC2025258/ /pubmed/974003 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Betton, G. R.
Owen, L. N.
Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title_full Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title_fullStr Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title_full_unstemmed Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title_short Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
title_sort allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025258/
https://www.ncbi.nlm.nih.gov/pubmed/974003
work_keys_str_mv AT bettongr allogeneicgraftsofspontaneouscaninemelanomasandtheircellculturestrainsinneonatalimmunosuppresseddogs
AT owenln allogeneicgraftsofspontaneouscaninemelanomasandtheircellculturestrainsinneonatalimmunosuppresseddogs

Ejemplares similares