Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.

The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, an...

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Detalles Bibliográficos
Autores principales: Clapp, M. J., Conning, D. M., Wilson, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025273/
https://www.ncbi.nlm.nih.gov/pubmed/851510
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author Clapp, M. J.
Conning, D. M.
Wilson, J.
author_facet Clapp, M. J.
Conning, D. M.
Wilson, J.
author_sort Clapp, M. J.
collection PubMed
description The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardized results have been analysed according to the Weibull distribution model. The results show that NSM condensate has less than 25% of the potency of tobacco condensate (37% at 95% upper confidence limit), and that condensates from blends of NSM and tobacco are similarly reduced in activity. General pathology analysis failed to reveal abnormalities due to NSM.
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spelling pubmed-20252732009-09-10 Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material. Clapp, M. J. Conning, D. M. Wilson, J. Br J Cancer Research Article The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardized results have been analysed according to the Weibull distribution model. The results show that NSM condensate has less than 25% of the potency of tobacco condensate (37% at 95% upper confidence limit), and that condensates from blends of NSM and tobacco are similarly reduced in activity. General pathology analysis failed to reveal abnormalities due to NSM. Nature Publishing Group 1977-03 /pmc/articles/PMC2025273/ /pubmed/851510 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Clapp, M. J.
Conning, D. M.
Wilson, J.
Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title_full Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title_fullStr Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title_full_unstemmed Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title_short Studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
title_sort studies on the local and systemic carcinogenicity of topically applied smoke condensate from a substitute smoking material.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025273/
https://www.ncbi.nlm.nih.gov/pubmed/851510
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AT wilsonj studiesonthelocalandsystemiccarcinogenicityoftopicallyappliedsmokecondensatefromasubstitutesmokingmaterial

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