Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.

Transplanted syngeneic osteosarcomas (induced by 32P in DA rats) grew significantly larger in DA rats receiving a simultaneous transplant of allogeneic osteosarcoma than in rats receiving syngeneic tumour only (P less than 0-01). Two other malignant allogeneic tumours, and allogeneic spleen cells, d...

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Autores principales: Geddes-Dwyer, V., Hersey, P., Cameron, D. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025295/
https://www.ncbi.nlm.nih.gov/pubmed/264382
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author Geddes-Dwyer, V.
Hersey, P.
Cameron, D. A.
author_facet Geddes-Dwyer, V.
Hersey, P.
Cameron, D. A.
author_sort Geddes-Dwyer, V.
collection PubMed
description Transplanted syngeneic osteosarcomas (induced by 32P in DA rats) grew significantly larger in DA rats receiving a simultaneous transplant of allogeneic osteosarcoma than in rats receiving syngeneic tumour only (P less than 0-01). Two other malignant allogeneic tumours, and allogeneic spleen cells, did not alter the growth of the transplanted syngeneic osteosarcomas. When the allogeneic osteosarcoma was given 7 days before the syngeneic tumour, the reverse effect (retardation) occurred. When given 7 days after the syngeneic tumour cells, the effect on both syngeneic and allogeneic tumour growth was variable. Some possible reasons for these findings are discussed, and the argument is presented that immunological phenonema are involved in the reaction. IMAGES:
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spelling pubmed-20252952009-09-10 Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts. Geddes-Dwyer, V. Hersey, P. Cameron, D. A. Br J Cancer Research Article Transplanted syngeneic osteosarcomas (induced by 32P in DA rats) grew significantly larger in DA rats receiving a simultaneous transplant of allogeneic osteosarcoma than in rats receiving syngeneic tumour only (P less than 0-01). Two other malignant allogeneic tumours, and allogeneic spleen cells, did not alter the growth of the transplanted syngeneic osteosarcomas. When the allogeneic osteosarcoma was given 7 days before the syngeneic tumour, the reverse effect (retardation) occurred. When given 7 days after the syngeneic tumour cells, the effect on both syngeneic and allogeneic tumour growth was variable. Some possible reasons for these findings are discussed, and the argument is presented that immunological phenonema are involved in the reaction. IMAGES: Nature Publishing Group 1977-01 /pmc/articles/PMC2025295/ /pubmed/264382 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Geddes-Dwyer, V.
Hersey, P.
Cameron, D. A.
Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title_full Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title_fullStr Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title_full_unstemmed Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title_short Enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
title_sort enhanced osteosarcoma growth produced in rats by osteosarcoma allografts.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025295/
https://www.ncbi.nlm.nih.gov/pubmed/264382
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