Cargando…
Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL).
The effects of long-term anticoagulation with phenprocoumon on growth of the Lewis lung carcinoma (3LL) were studied. Oral anticoagulation initiated at the day of i.m. transplantation of the 3LL into C57BL mice significantly inhibited primary tumour growth and reduced the number of spontaneous metas...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1977
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025311/ https://www.ncbi.nlm.nih.gov/pubmed/64254 |
_version_ | 1782136738547761152 |
---|---|
author | Hilgard, P. Schulte, H. Wetzig, G. Schmitt, G. Schmidt, C. G. |
author_facet | Hilgard, P. Schulte, H. Wetzig, G. Schmitt, G. Schmidt, C. G. |
author_sort | Hilgard, P. |
collection | PubMed |
description | The effects of long-term anticoagulation with phenprocoumon on growth of the Lewis lung carcinoma (3LL) were studied. Oral anticoagulation initiated at the day of i.m. transplantation of the 3LL into C57BL mice significantly inhibited primary tumour growth and reduced the number of spontaneous metastases to the lungs. Intermittent anticoagulation was without effect on metastasis formation but still retarded primary growth. There was no influence of anticoagulation on the mean survival time (MST) of tumour-bearing animals. Phenprocoumon appears to improve the results of cyclophosphamide of 5-fluorouracil treatment, but there were no statisticially significant differences. In contrast, bleomycin treatment in combination with adjuvant anticoagulation suggested a possible drug synergy. No significant influence of anticoagulation on the response of the primary tumour to irradiattion was found, though the MST of irradiated and anticoagulated animals was greater than in the solely irradiated controls. The present investigations suggest that coumarin derivatives have some direct tumour-inhibiting capacities, but exert their antimetastatic action via deceleration of the blood clotting mechanism. |
format | Text |
id | pubmed-2025311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1977 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20253112009-09-10 Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). Hilgard, P. Schulte, H. Wetzig, G. Schmitt, G. Schmidt, C. G. Br J Cancer Research Article The effects of long-term anticoagulation with phenprocoumon on growth of the Lewis lung carcinoma (3LL) were studied. Oral anticoagulation initiated at the day of i.m. transplantation of the 3LL into C57BL mice significantly inhibited primary tumour growth and reduced the number of spontaneous metastases to the lungs. Intermittent anticoagulation was without effect on metastasis formation but still retarded primary growth. There was no influence of anticoagulation on the mean survival time (MST) of tumour-bearing animals. Phenprocoumon appears to improve the results of cyclophosphamide of 5-fluorouracil treatment, but there were no statisticially significant differences. In contrast, bleomycin treatment in combination with adjuvant anticoagulation suggested a possible drug synergy. No significant influence of anticoagulation on the response of the primary tumour to irradiattion was found, though the MST of irradiated and anticoagulated animals was greater than in the solely irradiated controls. The present investigations suggest that coumarin derivatives have some direct tumour-inhibiting capacities, but exert their antimetastatic action via deceleration of the blood clotting mechanism. Nature Publishing Group 1977-01 /pmc/articles/PMC2025311/ /pubmed/64254 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Hilgard, P. Schulte, H. Wetzig, G. Schmitt, G. Schmidt, C. G. Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title | Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title_full | Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title_fullStr | Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title_full_unstemmed | Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title_short | Oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3LL). |
title_sort | oral anticoagulation in the treatment of a spontaneously metastasising murine tumour (3ll). |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025311/ https://www.ncbi.nlm.nih.gov/pubmed/64254 |
work_keys_str_mv | AT hilgardp oralanticoagulationinthetreatmentofaspontaneouslymetastasisingmurinetumour3ll AT schulteh oralanticoagulationinthetreatmentofaspontaneouslymetastasisingmurinetumour3ll AT wetzigg oralanticoagulationinthetreatmentofaspontaneouslymetastasisingmurinetumour3ll AT schmittg oralanticoagulationinthetreatmentofaspontaneouslymetastasisingmurinetumour3ll AT schmidtcg oralanticoagulationinthetreatmentofaspontaneouslymetastasisingmurinetumour3ll |