A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.

A line of human leukaemia-derived cells is described that kills a wide range of human and animal cell lines, whether normal or malignant, even at a ratio of 1:1. During exposure to the target cells, the killer cells released a factor into the culture medium which destroyed target cells in the absenc...

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Detalles Bibliográficos
Autor principal: Karpas, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025323/
https://www.ncbi.nlm.nih.gov/pubmed/300025
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author Karpas, A.
author_facet Karpas, A.
author_sort Karpas, A.
collection PubMed
description A line of human leukaemia-derived cells is described that kills a wide range of human and animal cell lines, whether normal or malignant, even at a ratio of 1:1. During exposure to the target cells, the killer cells released a factor into the culture medium which destroyed target cells in the absence of the killer cells. This phenomenon occurs without exogenous complement and requires no pre-treatment of target or killer cells. The humoral factor is a protein precipitable by 60% saturation of ammonium sulphate and has a mol. wt. of approximately 70,000; It prevented the growth of a fibrosarcoma in mice. IMAGES:
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spelling pubmed-20253232009-09-10 A human haemic cell line capable of cellular and humoral killing of normal and malignant cells. Karpas, A. Br J Cancer Research Article A line of human leukaemia-derived cells is described that kills a wide range of human and animal cell lines, whether normal or malignant, even at a ratio of 1:1. During exposure to the target cells, the killer cells released a factor into the culture medium which destroyed target cells in the absence of the killer cells. This phenomenon occurs without exogenous complement and requires no pre-treatment of target or killer cells. The humoral factor is a protein precipitable by 60% saturation of ammonium sulphate and has a mol. wt. of approximately 70,000; It prevented the growth of a fibrosarcoma in mice. IMAGES: Nature Publishing Group 1977-02 /pmc/articles/PMC2025323/ /pubmed/300025 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Karpas, A.
A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title_full A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title_fullStr A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title_full_unstemmed A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title_short A human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
title_sort human haemic cell line capable of cellular and humoral killing of normal and malignant cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025323/
https://www.ncbi.nlm.nih.gov/pubmed/300025
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