Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.

The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements...

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Detalles Bibliográficos
Autores principales: Ward, A. M., Cooper, E. H., Turner, R., Anderson, J. A., Neville, A. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025326/
https://www.ncbi.nlm.nih.gov/pubmed/13805
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author Ward, A. M.
Cooper, E. H.
Turner, R.
Anderson, J. A.
Neville, A. M.
author_facet Ward, A. M.
Cooper, E. H.
Turner, R.
Anderson, J. A.
Neville, A. M.
author_sort Ward, A. M.
collection PubMed
description The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.
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spelling pubmed-20253262009-09-10 Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes. Ward, A. M. Cooper, E. H. Turner, R. Anderson, J. A. Neville, A. M. Br J Cancer Research Article The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone. Nature Publishing Group 1977-02 /pmc/articles/PMC2025326/ /pubmed/13805 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ward, A. M.
Cooper, E. H.
Turner, R.
Anderson, J. A.
Neville, A. M.
Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title_full Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title_fullStr Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title_full_unstemmed Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title_short Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
title_sort acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by cea and serum enzymes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025326/
https://www.ncbi.nlm.nih.gov/pubmed/13805
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