Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.

Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of s...

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Autores principales: Guiliani, F., Casazza, A. M., Soranzo, C., Di Marco, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025332/
https://www.ncbi.nlm.nih.gov/pubmed/189792
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author Guiliani, F.
Casazza, A. M.
Soranzo, C.
Di Marco, A.
author_facet Guiliani, F.
Casazza, A. M.
Soranzo, C.
Di Marco, A.
author_sort Guiliani, F.
collection PubMed
description Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of sera which have low virus-neutralizing antibody content; (2) high effectiveness only of the IgG serum fraction; (3) inactivity of regressor serum incubated with anti-mouse gamma-globulin serum. The regressor serum activity was specific and could not be ascribed to interferon or interferon-inducing factors, antigen-antibody complexes or free antigen. The activity was not suppressed by sublethal irradiation (380 rad) of recipient mice. These results suggest that the activity of regressor serum administered before MSV-M infection is mediated through sensitization of host cells which are not radiosensitive.
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spelling pubmed-20253322009-09-10 Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth. Guiliani, F. Casazza, A. M. Soranzo, C. Di Marco, A. Br J Cancer Research Article Regressor serum from MSV-M-infected mice markedly reduced MSV-M oncogenesis when administered i.p. (0-1 ml/mouse) as much as 30 days before i.m. MSV-M infection in adult BALB/c mice. The regressor serum activity appeared to be directly dependent on the amount of IgG, as shown by: (1) inactivity of sera which have low virus-neutralizing antibody content; (2) high effectiveness only of the IgG serum fraction; (3) inactivity of regressor serum incubated with anti-mouse gamma-globulin serum. The regressor serum activity was specific and could not be ascribed to interferon or interferon-inducing factors, antigen-antibody complexes or free antigen. The activity was not suppressed by sublethal irradiation (380 rad) of recipient mice. These results suggest that the activity of regressor serum administered before MSV-M infection is mediated through sensitization of host cells which are not radiosensitive. Nature Publishing Group 1977-02 /pmc/articles/PMC2025332/ /pubmed/189792 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Guiliani, F.
Casazza, A. M.
Soranzo, C.
Di Marco, A.
Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title_full Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title_fullStr Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title_full_unstemmed Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title_short Effect of pretreatment with immune serum on murine sarcoma virus (Moloney) tumour induction and growth.
title_sort effect of pretreatment with immune serum on murine sarcoma virus (moloney) tumour induction and growth.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025332/
https://www.ncbi.nlm.nih.gov/pubmed/189792
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AT soranzoc effectofpretreatmentwithimmuneserumonmurinesarcomavirusmoloneytumourinductionandgrowth
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