Early central nervous system involvement in adults with acute non-myelogenous leukaemia.

Of 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40...

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Autores principales: Lister, T. A., Whitehouse, J. M., Beard, M. E., Paxton, A., Brearley, R. L., Brown, L., Wrigley, P. F., Crowther, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025338/
https://www.ncbi.nlm.nih.gov/pubmed/265731
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author Lister, T. A.
Whitehouse, J. M.
Beard, M. E.
Paxton, A.
Brearley, R. L.
Brown, L.
Wrigley, P. F.
Crowther, D.
author_facet Lister, T. A.
Whitehouse, J. M.
Beard, M. E.
Paxton, A.
Brearley, R. L.
Brown, L.
Wrigley, P. F.
Crowther, D.
author_sort Lister, T. A.
collection PubMed
description Of 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia.
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spelling pubmed-20253382009-09-10 Early central nervous system involvement in adults with acute non-myelogenous leukaemia. Lister, T. A. Whitehouse, J. M. Beard, M. E. Paxton, A. Brearley, R. L. Brown, L. Wrigley, P. F. Crowther, D. Br J Cancer Research Article Of 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia. Nature Publishing Group 1977-04 /pmc/articles/PMC2025338/ /pubmed/265731 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lister, T. A.
Whitehouse, J. M.
Beard, M. E.
Paxton, A.
Brearley, R. L.
Brown, L.
Wrigley, P. F.
Crowther, D.
Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title_full Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title_fullStr Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title_full_unstemmed Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title_short Early central nervous system involvement in adults with acute non-myelogenous leukaemia.
title_sort early central nervous system involvement in adults with acute non-myelogenous leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025338/
https://www.ncbi.nlm.nih.gov/pubmed/265731
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