Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.

Mice were exposed to plutonium dioxide (PuO2) aerosols 2 weeks before or after urethan injection. Both exposures reduced the number and size of adenomas. The incidence of arrested metaphases showed no consistently significant differences between plutonium-exposed and mock-exposed animals. The result...

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Detalles Bibliográficos
Autores principales: Brightwell, J., Heppleston, A. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1977
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025349/
https://www.ncbi.nlm.nih.gov/pubmed/857826
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author Brightwell, J.
Heppleston, A. G.
author_facet Brightwell, J.
Heppleston, A. G.
author_sort Brightwell, J.
collection PubMed
description Mice were exposed to plutonium dioxide (PuO2) aerosols 2 weeks before or after urethan injection. Both exposures reduced the number and size of adenomas. The incidence of arrested metaphases showed no consistently significant differences between plutonium-exposed and mock-exposed animals. The results are discussed in relation to recent electron microscopic evidence of degenerative changes in the type II epithelial cells of the mouse lung following PuO2 inhalation. It is concluded that damage at the cellular level may account for the observed reduction in growth of pulmonary adenomas in mice whose lungs contained plutonium particles.
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spelling pubmed-20253492009-09-10 Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas. Brightwell, J. Heppleston, A. G. Br J Cancer Research Article Mice were exposed to plutonium dioxide (PuO2) aerosols 2 weeks before or after urethan injection. Both exposures reduced the number and size of adenomas. The incidence of arrested metaphases showed no consistently significant differences between plutonium-exposed and mock-exposed animals. The results are discussed in relation to recent electron microscopic evidence of degenerative changes in the type II epithelial cells of the mouse lung following PuO2 inhalation. It is concluded that damage at the cellular level may account for the observed reduction in growth of pulmonary adenomas in mice whose lungs contained plutonium particles. Nature Publishing Group 1977-04 /pmc/articles/PMC2025349/ /pubmed/857826 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Brightwell, J.
Heppleston, A. G.
Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title_full Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title_fullStr Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title_full_unstemmed Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title_short Effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
title_sort effect of inhaled plutonium dioxide on development of urethan-induced pulmonary adenomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025349/
https://www.ncbi.nlm.nih.gov/pubmed/857826
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